Oral Cancer: Pathogenesis

All types of carcinomas are seen in oral cavity, the most common form of OC is squamous cell carcinoma. Use of genetic and proteomic approach in recent years have revealed the molecular pathological picture of Oral Cancer. Genetic alterations define molecular basis of carcinogenesis which includes point mutations, amplifications, rearrangements and deletions. Several oncogenes have also been implicated in oral carcinogenesis. Genomic instability such as loss of hetrozygosity and microsatellite instability are frequently observed in cancer and such instability has been investigated and several reports are available in Oral Cancer.  

  • Oral squamous cell carcinoma
  • Multistep carcinogenesis
  • Oncogene
  • Tumor suppressor gene
  • Genomic instability

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